Thursday, January 10, 2013

Gene Therapy for Salivary Gland Shows Promise | Reduction

Gene Therapy for Salivary Gland Shows Promise

Basal Cell Adenoma of Parotid Gland
Basal Cell Adenoma of Parotid Gland by euthman
License (according to Flickr): Attribution License
Excerpt:

An experimental trial revealed that gene therapy could be performed safely in the human salivary gland. The accomplishment might one day cause treatments to help head and neck cancer survivors who battle with chronic dry mouth. A mouse embryonic salivary gland. Credit: Melinda Larsen et al. , Developmental Biology 255: 178-191, 2003. Individuals with head and neck cancer often obtain radiation therapy to shrink their tumors. The radiation could damage salivary glands, minimizing their capability to secrete saliva into the mouth. Saliva is needed for taste, swallowing and speech. It also helps avoid infection and tooth decay. Salivary glands might mostly recover after radiation therapy, however recovery is normally not complete. Physicians have limited choices to provide a lot of clients.

Keywords:

salivary gland salivary glands gene salivary gland cells gene therapy neck cancer neck cancer survivors embryonic salivary gland human salivary gland parotid salivary glands major salivary glands aquaporin-1 gene dry mouth animal models secretion radiation therapy immune response short-lived gene expression chronic dry mouth saliva secretion virus Dr. Bruce Baum NIH Clinical Center pore-like water channels small clinical trial 42-day study period minimal immune response gene transfer head Melinda Larsen experimental trial NIH s National scientists Developmental Biology therapy studies tooth decay Aquaporin-1 forms early 1990s Craniofacial Research research clinics cell membranes single-dose infusion different doses disabled adenovirus common cold delivery vehicle disabled virus higher doses National Academy renewed sense

People:

Baum

Overall Sentiment: 0.0184703

Relevance: 0.754602

SentimentQuote
0“It is time to evaluate a different vector to deliver the aquaporin-1 gene, one that will cause only a minimal immune response,” Baum says. ...
0.0737217“These data will serve as stepping stones for other scientists to improve on this first attempt in the years ahead,” says Baum.
0.0792426“These data will serve as stepping stones for other scientists to improve on this first attempt in the years ahead,” says Baum. “The future for applications of gene therapy in the salivary gland is bright.”
Sentiment Stats:
  • Number of Quotes: 3
  • Aggregate Sentiment: 0.1529643
  • Mean: 0.0509881
  • Standard Deviation: 1.4142135623731
Disambiguation: Dedicator | FictionalUniverseCreator | FilmDirector | FilmProducer | FilmActor | FilmWriterReferences:

Dr. Bruce Baum

Overall Sentiment: 0.0323458

Relevance: 0.709402

Disambiguation: References:

Melinda Larsen

Overall Sentiment: 0.100323

Relevance: 0.526358

Key:

  • Aggregate Sentiment is meant to be an indicator of an individual's overall sentiment.
  • The Mean is meant to be an indicator of an individual's average comment sentiment.
  • The Standard Deviation, when there are enough quotes, will indicate an individual's consistency of sentiment (i.e. a Standard Deviation of 0 would mean they were very consistent in their sentiment and 1 would mean they were very inconsistent).

Note that quote stats are likely to be meaningless beyond the aggregate score due to the tiny sample size. However, they are always provided just in case you find something useful there.

Additional Info:

Organization: NIH

Overall Sentiment: -0.181389

Relevance: 0.676002

Organization: NIDCR

Overall Sentiment: -0.0690152

Relevance: 0.654123

Organization: National Academy of Sciences

Overall Sentiment: 0

Relevance: 0.51246

Organization: NIH Clinical Center

Overall Sentiment: -0.299324

Relevance: 0.470985

Organization: National Institute of Dental and Craniofacial Research

Overall Sentiment: 0.165929

Relevance: 0.457532

PrintMedia: Developmental Biology

Overall Sentiment: 0.0361963

Relevance: 0.650021

HealthCondition: cancer

Overall Sentiment: 0

Relevance: 0.923158

Disambiguation: FieldOfStudy | DiseaseOrMedicalCondition | CauseOfDeath | DiseaseCause | MedicalSpecialty | RiskFactor | DiseaseReferences:

HealthCondition: tumors

Overall Sentiment: -0.266406

Relevance: 0.459125

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