Wednesday, December 12, 2012

Aspirin coating may impact drug's effectiveness | Essentials

Aspirin coating may impact drug's effectiveness

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Excerpt:

Researchers are challenging the common medical belief that some people's genes make them resistant to the heart-protective benefits of aspirin, reporting in a study that the coating on some tablets is the likely cause. In a report involving 400 healthy patients screened for their response to a single dose of either plain aspirin or a coated pill, "We couldn't find any people who were truly resistant," said Garret FitzGerald, head of the Institute for Translational Medicine and Therapeutics at the University of Pennsylvania, Philadelphia, and senior author of the report. A daily low-dose aspirin—typically 81 to 162 milligrams—is a mainstay strategy to prevent heart attacks in men and strokes in women. Aspirin is also given to patients suffering heart attacks and prescribed to those whose blocked arteries have been treated with bypass surgery or propped open with a metal device called a stent.

People:

Garret FitzGerald

Overall Sentiment: 0.240262

Relevance: 0.234963

SentimentQuote
0"nonresponders" had taken a coated tablet, Dr. FitzGerald said. ...
Sentiment Stats:
  • Number of Quotes: 1
  • Aggregate Sentiment: 0
  • Mean: 0
  • Standard Deviation: 1.4142135623731

Bayer

Overall Sentiment: 0

Relevance: 0.161411

Disambiguation: References:

Robert Bonow

Overall Sentiment: -0.015252

Relevance: 0.110307

Key:

  • Aggregate Sentiment is meant to be an indicator of an individual's overall sentiment.
  • The Mean is meant to be an indicator of an individual's average comment sentiment.
  • The Standard Deviation, when there are enough quotes, will indicate an individual's consistency of sentiment (i.e. a Standard Deviation of 0 would mean they were very consistent in their sentiment and 1 would mean they were very inconsistent).

Note that quote stats are likely to be meaningless beyond the aggregate score due to the tiny sample size. However, they are always provided just in case you find something useful there.

Additional Info:

Drug: aspirin

Overall Sentiment: 0.218632

Relevance: 0.92713

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